Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4846623..4847407 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag FG550_RS23200 Protein ID WP_000613626.1
Coordinates 4846623..4847117 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag FG550_RS23205 Protein ID WP_001110447.1
Coordinates 4847114..4847407 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS23180 (4841816) 4841816..4842913 + 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -
FG550_RS23185 (4842913) 4842913..4843854 + 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
FG550_RS23190 (4843920) 4843920..4845563 + 1644 WP_000096478.1 flagellar hook-associated protein FlgK -
FG550_RS23195 (4845575) 4845575..4846528 + 954 WP_001212768.1 flagellar hook-associated protein FlgL -
FG550_RS23200 (4846623) 4846623..4847117 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
FG550_RS23205 (4847114) 4847114..4847407 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
FG550_RS23210 (4847540) 4847540..4850725 - 3186 WP_001550951.1 ribonuclease E -
FG550_RS23215 (4851298) 4851298..4852257 + 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T265764 WP_000613626.1 NZ_CP113486:c4847117-4846623 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT265764 WP_001110447.1 NZ_CP113486:c4847407-4847114 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References