Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4590598..4591303 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag FG550_RS21985 Protein ID WP_000539521.1
Coordinates 4590917..4591303 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FG550_RS21980 Protein ID WP_001280945.1
Coordinates 4590598..4590927 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS21965 (4585755) 4585755..4586666 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
FG550_RS21970 (4586844) 4586844..4589192 + 2349 WP_001550886.1 EAL domain-containing protein -
FG550_RS21975 (4589200) 4589200..4590528 + 1329 WP_001550887.1 GGDEF domain-containing protein -
FG550_RS21980 (4590598) 4590598..4590927 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
FG550_RS21985 (4590917) 4590917..4591303 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FG550_RS21990 (4591529) 4591529..4592854 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
FG550_RS21995 (4593067) 4593067..4593450 + 384 WP_000497137.1 biofilm formation regulator BssR -
FG550_RS22000 (4593561) 4593561..4594676 + 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
FG550_RS22005 (4594673) 4594673..4595299 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T265763 WP_000539521.1 NZ_CP113486:c4591303-4590917 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT265763 WP_001280945.1 NZ_CP113486:c4590927-4590598 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References