Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4137723..4138341 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FG550_RS19865 Protein ID WP_001291435.1
Coordinates 4137723..4137941 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FG550_RS19870 Protein ID WP_000344800.1
Coordinates 4137967..4138341 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS19830 (4133012) 4133012..4133584 + 573 WP_000779831.1 YbaY family lipoprotein -
FG550_RS19835 (4133615) 4133615..4133926 - 312 WP_000409911.1 MGMT family protein -
FG550_RS19845 (4134305) 4134305..4134658 + 354 WP_001550741.1 DUF1428 family protein -
FG550_RS19850 (4134700) 4134700..4136250 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FG550_RS19855 (4136414) 4136414..4136884 - 471 WP_000136192.1 YlaC family protein -
FG550_RS19860 (4137000) 4137000..4137551 - 552 WP_000102564.1 maltose O-acetyltransferase -
FG550_RS19865 (4137723) 4137723..4137941 - 219 WP_001291435.1 HHA domain-containing protein Toxin
FG550_RS19870 (4137967) 4137967..4138341 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FG550_RS19875 (4138887) 4138887..4142036 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
FG550_RS19880 (4142059) 4142059..4143252 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T265762 WP_001291435.1 NZ_CP113486:c4137941-4137723 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT265762 WP_000344800.1 NZ_CP113486:c4138341-4137967 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References