Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 922933..923409 Replicon chromosome
Accession NC_017333
Organism Staphylococcus aureus subsp. aureus ST398

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAPIG_RS04545 Protein ID WP_000052076.1
Coordinates 922933..923121 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAPIG_RS04550 Protein ID WP_001059690.1
Coordinates 923149..923409 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAPIG_RS04515 918962..919444 + 483 WP_000824489.1 hypothetical protein -
SAPIG_RS04520 919785..920471 + 687 WP_001574556.1 thermonuclease family protein -
SAPIG_RS04525 920828..921028 + 201 WP_001059082.1 cold-shock protein -
SAPIG_RS04530 921525..921743 - 219 WP_000005881.1 hypothetical protein -
SAPIG_RS04535 921804..922088 - 285 WP_001004403.1 hypothetical protein -
SAPIG_RS04540 922176..922745 - 570 WP_001106655.1 hypothetical protein -
SAPIG_RS04545 922933..923121 - 189 WP_000052076.1 hypothetical protein Toxin
SAPIG_RS04550 923149..923409 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAPIG_RS04555 923751..923954 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAPIG_RS04560 923951..924187 - 237 WP_000368687.1 hypothetical protein -
SAPIG_RS04565 924412..924993 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SAPIG_RS04570 925066..925683 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
SAPIG_RS04575 925832..926326 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SAPIG_RS04580 926725..927147 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
SAPIG_RS04585 927295..928011 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T26576 WP_000052076.1 NC_017333:c923121-922933 [Staphylococcus aureus subsp. aureus ST398]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26576 NC_017333:c923121-922933 [Staphylococcus aureus subsp. aureus ST398]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26576 WP_001059690.1 NC_017333:c923409-923149 [Staphylococcus aureus subsp. aureus ST398]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26576 NC_017333:c923409-923149 [Staphylococcus aureus subsp. aureus ST398]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References