Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3390064..3390586 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag FG550_RS16265 Protein ID WP_001105433.1
Coordinates 3390296..3390586 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag FG550_RS16260 Protein ID WP_000212715.1
Coordinates 3390064..3390306 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS16240 (3385783) 3385783..3387156 + 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
FG550_RS16245 (3387306) 3387306..3387857 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
FG550_RS16250 (3387951) 3387951..3389303 + 1353 WP_001162173.1 metalloprotease PmbA -
FG550_RS16255 (3389486) 3389486..3389872 + 387 WP_001232246.1 cytochrome b562 -
FG550_RS16260 (3390064) 3390064..3390306 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FG550_RS16265 (3390296) 3390296..3390586 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FG550_RS16270 (3390587) 3390587..3391051 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FG550_RS16275 (3391231) 3391231..3393369 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
FG550_RS16280 (3393763) 3393763..3395418 - 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T265757 WP_001105433.1 NZ_CP113486:3390296-3390586 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT265757 WP_000212715.1 NZ_CP113486:3390064-3390306 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References