265756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3378329..3378924 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag FG550_RS16205 Protein ID WP_019842229.1
Coordinates 3378574..3378924 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag FG550_RS16200 Protein ID WP_001223213.1
Coordinates 3378329..3378580 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS16190 (3373994) 3373994..3377773 + 3780 WP_001550503.1 autotransporter assembly complex protein TamB -
FG550_RS16195 (3377776) 3377776..3378117 + 342 WP_001550504.1 gamma-glutamylcyclotransferase -
FG550_RS16200 (3378329) 3378329..3378580 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FG550_RS16205 (3378574) 3378574..3378924 + 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
FG550_RS16210 (3379128) 3379128..3379658 - 531 WP_000055075.1 inorganic diphosphatase -
FG550_RS16215 (3379968) 3379968..3380924 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FG550_RS16220 (3381056) 3381056..3382558 + 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
FG550_RS16225 (3382572) 3382572..3383594 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T265756 WP_019842229.1 NZ_CP113486:3378574-3378924 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT265756 WP_001223213.1 NZ_CP113486:3378329-3378580 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References