Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3281290..3281787 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag FG550_RS15700 Protein ID WP_001173343.1
Coordinates 3281614..3281787 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag FG550_RS15695 Protein ID WP_000398619.1
Coordinates 3281290..3281586 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS15675 (3278020) 3278020..3278739 - 720 WP_000611288.1 two-component system response regulator DcuR -
FG550_RS15680 (3278736) 3278736..3280367 - 1632 WP_001216477.1 sensor histidine kinase -
FG550_RS15685 (3280547) 3280547..3280777 + 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
FG550_RS15690 (3280789) 3280789..3281061 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
FG550_RS15695 (3281290) 3281290..3281586 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
FG550_RS15700 (3281614) 3281614..3281787 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
FG550_RS15705 (3281906) 3281906..3283423 - 1518 WP_001550472.1 lysine--tRNA ligase -
FG550_RS15710 (3283660) 3283660..3285117 - 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T265755 WP_001173343.1 NZ_CP113486:3281614-3281787 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT265755 WP_000398619.1 NZ_CP113486:3281290-3281586 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References