Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2621926..2622538 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag FG550_RS12735 Protein ID WP_000833473.1
Coordinates 2622353..2622538 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag FG550_RS12730 Protein ID WP_000499744.1
Coordinates 2621926..2622336 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS12715 (2617438) 2617438..2618253 - 816 WP_000891823.1 AraC family transcriptional regulator -
FG550_RS12720 (2618479) 2618479..2619879 + 1401 WP_268101361.1 MFS transporter -
FG550_RS12725 (2619890) 2619890..2621854 + 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
FG550_RS12730 (2621926) 2621926..2622336 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FG550_RS12735 (2622353) 2622353..2622538 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
FG550_RS12740 (2622807) 2622807..2624345 - 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
FG550_RS12745 (2624546) 2624546..2625697 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T265753 WP_000833473.1 NZ_CP113486:c2622538-2622353 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT265753 WP_000499744.1 NZ_CP113486:c2622336-2621926 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References