Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1761268..1761922 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag FG550_RS08435 Protein ID WP_000244781.1
Coordinates 1761268..1761675 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag FG550_RS08440 Protein ID WP_001564007.1
Coordinates 1761656..1761922 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS08415 (1757225) 1757225..1758958 - 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -
FG550_RS08420 (1758964) 1758964..1759674 - 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FG550_RS08425 (1759699) 1759699..1760595 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FG550_RS08430 (1760707) 1760707..1761228 + 522 WP_001055874.1 flavodoxin FldB -
FG550_RS08435 (1761268) 1761268..1761675 - 408 WP_000244781.1 protein YgfX Toxin
FG550_RS08440 (1761656) 1761656..1761922 - 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
FG550_RS08445 (1762165) 1762165..1763145 + 981 WP_001564008.1 tRNA-modifying protein YgfZ -
FG550_RS08450 (1763222) 1763222..1763881 - 660 WP_000250274.1 hemolysin III family protein -
FG550_RS08455 (1764045) 1764045..1764356 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
FG550_RS08460 (1764401) 1764401..1765834 + 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T265749 WP_000244781.1 NZ_CP113486:c1761675-1761268 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT265749 WP_001564007.1 NZ_CP113486:c1761922-1761656 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References