Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 107640..108278 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag FG550_RS00500 Protein ID WP_000813795.1
Coordinates 107640..107816 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FG550_RS00505 Protein ID WP_076797675.1
Coordinates 107862..108278 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS00480 (103262) 103262..104473 - 1212 WP_071591517.1 BenE family transporter YdcO -
FG550_RS00485 (104526) 104526..105062 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
FG550_RS00490 (105135) 105135..107096 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
FG550_RS00495 (107188) 107188..107418 - 231 WP_023910283.1 YncJ family protein -
FG550_RS00500 (107640) 107640..107816 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
FG550_RS00505 (107862) 107862..108278 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
FG550_RS00510 (108357) 108357..109763 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
FG550_RS00515 (110008) 110008..111153 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
FG550_RS00520 (111171) 111171..112184 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
FG550_RS00525 (112185) 112185..113126 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T265739 WP_000813795.1 NZ_CP113486:107640-107816 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT265739 WP_076797675.1 NZ_CP113486:107862-108278 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References