Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3398683..3399336 Replicon chromosome
Accession NZ_CP113485
Organism Mycobacterium avium subsp. paratuberculosis strain LN20

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag OUZ54_RS15880 Protein ID WP_003872880.1
Coordinates 3398683..3399144 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q742J1
Locus tag OUZ54_RS15885 Protein ID WP_003872881.1
Coordinates 3399148..3399336 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUZ54_RS15855 (OUZ54_15855) 3394048..3394386 - 339 WP_016705559.1 hypothetical protein -
OUZ54_RS15860 (OUZ54_15860) 3394922..3395140 + 219 WP_016705560.1 hypothetical protein -
OUZ54_RS15865 (OUZ54_15865) 3395175..3395561 - 387 WP_003872877.1 hypothetical protein -
OUZ54_RS15870 (OUZ54_15870) 3395601..3397184 - 1584 WP_170936827.1 DUF4185 domain-containing protein -
OUZ54_RS15875 (OUZ54_15875) 3398180..3398614 - 435 WP_003872879.1 hypothetical protein -
OUZ54_RS15880 (OUZ54_15880) 3398683..3399144 - 462 WP_003872880.1 SRPBCC family protein Toxin
OUZ54_RS15885 (OUZ54_15885) 3399148..3399336 - 189 WP_003872881.1 antitoxin Antitoxin
OUZ54_RS15890 (OUZ54_15890) 3399399..3401771 - 2373 WP_003872882.1 HAD-IC family P-type ATPase -
OUZ54_RS15895 (OUZ54_15895) 3401768..3403354 - 1587 WP_094028703.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(2-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16626.19 Da        Isoelectric Point: 9.5654

>T265737 WP_003872880.1 NZ_CP113485:c3399144-3398683 [Mycobacterium avium subsp. paratuberculosis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Download         Length: 462 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6745.42 Da        Isoelectric Point: 4.4865

>AT265737 WP_003872881.1 NZ_CP113485:c3399336-3399148 [Mycobacterium avium subsp. paratuberculosis]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2WC18

References