Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/ParD(antitoxin) |
| Location | 2191032..2192030 | Replicon | chromosome |
| Accession | NZ_CP113485 | ||
| Organism | Mycobacterium avium subsp. paratuberculosis strain LN20 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | X7VT18 |
| Locus tag | OUZ54_RS10515 | Protein ID | WP_003876749.1 |
| Coordinates | 2191452..2192030 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | OUZ54_RS10510 | Protein ID | WP_003876750.1 |
| Coordinates | 2191032..2191421 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OUZ54_RS10490 (OUZ54_10490) | 2186167..2186847 | - | 681 | WP_010949357.1 | hypothetical protein | - |
| OUZ54_RS10495 (OUZ54_10495) | 2186927..2188444 | + | 1518 | WP_016706331.1 | carboxylesterase/lipase family protein | - |
| OUZ54_RS10500 (OUZ54_10500) | 2188463..2190460 | + | 1998 | WP_003876752.1 | phosphotransferase | - |
| OUZ54_RS10505 (OUZ54_10505) | 2190457..2190951 | + | 495 | WP_010949355.1 | gluconokinase | - |
| OUZ54_RS10510 (OUZ54_10510) | 2191032..2191421 | + | 390 | WP_003876750.1 | hypothetical protein | Antitoxin |
| OUZ54_RS10515 (OUZ54_10515) | 2191452..2192030 | + | 579 | WP_003876749.1 | zeta toxin family protein | Toxin |
| OUZ54_RS10520 (OUZ54_10520) | 2192035..2193102 | - | 1068 | WP_003876748.1 | DoxX family protein | - |
| OUZ54_RS10525 (OUZ54_10525) | 2193213..2193773 | + | 561 | WP_003878040.1 | pyrazinamidase PncA | - |
| OUZ54_RS10530 (OUZ54_10530) | 2193773..2194573 | + | 801 | WP_003876746.1 | nuclear transport factor 2 family protein | - |
| OUZ54_RS10535 (OUZ54_10535) | 2194587..2194937 | - | 351 | WP_003878038.1 | DoxX family protein | - |
| OUZ54_RS10540 (OUZ54_10540) | 2195257..2196477 | + | 1221 | WP_010948702.1 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2195278..2196477 | 1199 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21034.18 Da Isoelectric Point: 10.6678
>T265736 WP_003876749.1 NZ_CP113485:2191452-2192030 [Mycobacterium avium subsp. paratuberculosis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV
Download Length: 579 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13569.99 Da Isoelectric Point: 5.6717
>AT265736 WP_003876750.1 NZ_CP113485:2191032-2191421 [Mycobacterium avium subsp. paratuberculosis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTAEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTAEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|