Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 1893541..1894205 Replicon chromosome
Accession NZ_CP113485
Organism Mycobacterium avium subsp. paratuberculosis strain LN20

Toxin (Protein)


Gene name vapC Uniprot ID Q73YC9
Locus tag OUZ54_RS09215 Protein ID WP_003872398.1
Coordinates 1893798..1894205 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q73YC8
Locus tag OUZ54_RS09210 Protein ID WP_003872399.1
Coordinates 1893541..1893801 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUZ54_RS09190 (OUZ54_09190) 1888957..1889619 + 663 WP_003872403.1 TetR/AcrR family transcriptional regulator -
OUZ54_RS09195 (OUZ54_09195) 1889815..1891272 + 1458 WP_268163624.1 serine/threonine-protein kinase -
OUZ54_RS09200 (OUZ54_09200) 1891474..1892742 - 1269 WP_003872401.1 cytochrome P450 -
OUZ54_RS09205 (OUZ54_09205) 1892908..1893360 + 453 WP_003872400.1 VOC family protein -
OUZ54_RS09210 (OUZ54_09210) 1893541..1893801 + 261 WP_003872399.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OUZ54_RS09215 (OUZ54_09215) 1893798..1894205 + 408 WP_003872398.1 type II toxin-antitoxin system VapC family toxin Toxin
OUZ54_RS09220 (OUZ54_09220) 1894352..1895917 - 1566 WP_003872397.1 serine/threonine-protein kinase -
OUZ54_RS09225 (OUZ54_09225) 1896154..1896675 + 522 WP_003878215.1 carboxymuconolactone decarboxylase family protein -
OUZ54_RS09230 (OUZ54_09230) 1896672..1897217 + 546 WP_003878214.1 carboxymuconolactone decarboxylase family protein -
OUZ54_RS09235 (OUZ54_09235) 1897338..1897868 + 531 WP_003878213.1 TetR/AcrR family transcriptional regulator -
OUZ54_RS09240 (OUZ54_09240) 1897857..1899030 - 1174 Protein_1822 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14418.47 Da        Isoelectric Point: 4.5642

>T265735 WP_003872398.1 NZ_CP113485:1893798-1894205 [Mycobacterium avium subsp. paratuberculosis]
MTARPAAGVLDTSVFIASESGRQLDEARIPDEVATTVVTLAELHAGVLAATTSNVRAQRLATLESIADMEMLPVDDDAVR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9635.01 Da        Isoelectric Point: 11.7137

>AT265735 WP_003872399.1 NZ_CP113485:1893541-1893801 [Mycobacterium avium subsp. paratuberculosis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTPLRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L5MIC8

Antitoxin

Source ID Structure
AlphaFold DB A0A7L5MIC5

References