Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4940..5562 Replicon plasmid pC9_4
Accession NZ_CP113446
Organism Acinetobacter baumannii strain C9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OQH41_RS19105 Protein ID WP_049173621.1
Coordinates 4940..5335 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3D2SL40
Locus tag OQH41_RS19110 Protein ID WP_049173623.1
Coordinates 5332..5562 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH41_RS19080 (OQH41_19080) 1..936 + 936 WP_049173632.1 replication initiation protein RepM -
OQH41_RS19085 (OQH41_19085) 1005..1550 + 546 WP_171249447.1 plasmid replication DNA-binding protein -
OQH41_RS19090 (OQH41_19090) 1984..2484 + 501 WP_049173636.1 hypothetical protein -
OQH41_RS19095 (OQH41_19095) 2477..3025 + 549 WP_049173638.1 DUF4062 domain-containing protein -
OQH41_RS19100 (OQH41_19100) 3029..4351 + 1323 WP_049173641.1 hypothetical protein -
OQH41_RS19105 (OQH41_19105) 4940..5335 - 396 WP_049173621.1 type II toxin-antitoxin system VapC family toxin Toxin
OQH41_RS19110 (OQH41_19110) 5332..5562 - 231 WP_049173623.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OQH41_RS19115 (OQH41_19115) 6171..6620 + 450 WP_049173625.1 hypothetical protein -
OQH41_RS19120 (OQH41_19120) 7326..7529 - 204 WP_049173627.1 hypothetical protein -
OQH41_RS19125 (OQH41_19125) 7556..7888 - 333 WP_049173629.1 type II toxin-antitoxin system YafQ family toxin -
OQH41_RS19130 (OQH41_19130) 7866..8141 - 276 WP_049173631.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8916 8916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14893.16 Da        Isoelectric Point: 6.2238

>T265733 WP_049173621.1 NZ_CP113446:c5335-4940 [Acinetobacter baumannii]
MIYLLDTNICIYVINNKPQHVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDDQAIWHYA
KLRQDLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8779.07 Da        Isoelectric Point: 4.7708

>AT265733 WP_049173623.1 NZ_CP113446:c5562-5332 [Acinetobacter baumannii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDIMLEAINEFEVGFQLERADQGEQFREEFK

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3D2SL40

References