Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2002502..2004138 Replicon chromosome
Accession NZ_CP113442
Organism Acinetobacter baumannii strain C9

Toxin (Protein)


Gene name hipA Uniprot ID A0A9F1U5K1
Locus tag OQH41_RS09545 Protein ID WP_005128640.1
Coordinates 2002807..2004138 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OQH41_RS09540 Protein ID WP_001101310.1
Coordinates 2002502..2002810 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH41_RS09515 (OQH41_09515) 1997865..1998578 + 714 WP_005128644.1 hypothetical protein -
OQH41_RS09520 (OQH41_09520) 1998591..1999700 + 1110 WP_005128643.1 XRE family transcriptional regulator -
OQH41_RS09525 (OQH41_09525) 1999763..2000311 - 549 WP_005128641.1 TetR/AcrR family transcriptional regulator -
OQH41_RS09530 (OQH41_09530) 2000734..2001243 + 510 WP_001122273.1 helix-turn-helix domain-containing protein -
OQH41_RS09535 (OQH41_09535) 2001276..2002118 + 843 WP_223673390.1 IS3 family transposase -
OQH41_RS09540 (OQH41_09540) 2002502..2002810 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OQH41_RS09545 (OQH41_09545) 2002807..2004138 - 1332 WP_005128640.1 HipA domain-containing protein Toxin
OQH41_RS09550 (OQH41_09550) 2004434..2004874 + 441 WP_000193136.1 HD domain-containing protein -
OQH41_RS09555 (OQH41_09555) 2004909..2005553 - 645 WP_005128638.1 hypothetical protein -
OQH41_RS09560 (OQH41_09560) 2005565..2006536 - 972 WP_086267245.1 5'/3'-nucleotidase SurE -
OQH41_RS09565 (OQH41_09565) 2006663..2007826 - 1164 WP_030423651.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.25 Da        Isoelectric Point: 4.8549

>T265729 WP_005128640.1 NZ_CP113442:c2004138-2002807 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT265729 WP_001101310.1 NZ_CP113442:c2002810-2002502 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References