Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 759976..760654 Replicon chromosome
Accession NZ_CP113442
Organism Acinetobacter baumannii strain C9

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OQH41_RS03595 Protein ID WP_000009390.1
Coordinates 760475..760654 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OQH41_RS03590 Protein ID WP_005112025.1
Coordinates 759976..760389 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH41_RS03555 (OQH41_03555) 755577..756797 + 1221 WP_005129596.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -
OQH41_RS03560 (OQH41_03560) 756944..758008 + 1065 WP_001278262.1 quinolinate synthase NadA -
OQH41_RS03585 (OQH41_03585) 759201..759719 + 519 WP_031945607.1 hypothetical protein -
OQH41_RS03590 (OQH41_03590) 759976..760389 - 414 WP_005112025.1 hypothetical protein Antitoxin
OQH41_RS03595 (OQH41_03595) 760475..760654 - 180 WP_000009390.1 type II toxin-antitoxin system HicA family toxin Toxin
OQH41_RS03600 (OQH41_03600) 760762..760977 - 216 WP_227552920.1 hypothetical protein -
OQH41_RS03605 (OQH41_03605) 760988..762034 - 1047 WP_194299481.1 phage portal protein -
OQH41_RS03610 (OQH41_03610) 762031..763809 - 1779 WP_005112022.1 terminase family protein -
OQH41_RS03615 (OQH41_03615) 763988..764839 + 852 WP_005112021.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 759976..795255 35279
- inside Prophage - - 759976..799496 39520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(16-78)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6799.11 Da        Isoelectric Point: 11.1422

>T265728 WP_000009390.1 NZ_CP113442:c760654-760475 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Download         Length: 180 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.75 Da        Isoelectric Point: 6.2451

>AT265728 WP_005112025.1 NZ_CP113442:c760389-759976 [Acinetobacter baumannii]
MKCYVSIHREGEAFIVSSSELPELNSVGYTLEEALSEALDGIETVFEIYMDERKAIPLPSKGKKGEYVVHLPVRVAAKVR
LYNEMISQNVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFQALGKDLDIVIA

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References