Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1610722..1611830 Replicon chromosome
Accession NZ_CP113440
Organism Streptococcus macedonicus strain E37

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag OQG81_RS08500 Protein ID WP_000233000.1
Coordinates 1610722..1611591 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag OQG81_RS08505 Protein ID WP_000205227.1
Coordinates 1611606..1611830 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQG81_RS08470 (OQG81_08470) 1605850..1605933 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
OQG81_RS08475 (OQG81_08475) 1606475..1607269 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
OQG81_RS08485 (OQG81_08485) 1608589..1609069 - 481 Protein_1618 GNAT family N-acetyltransferase -
OQG81_RS08490 (OQG81_08490) 1609066..1609974 - 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
OQG81_RS08495 (OQG81_08495) 1610007..1610741 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
OQG81_RS08500 (OQG81_08500) 1610722..1611591 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
OQG81_RS08505 (OQG81_08505) 1611606..1611830 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
OQG81_RS08510 (OQG81_08510) 1611973..1612059 - 87 Protein_1623 site-specific recombinase -
OQG81_RS08515 (OQG81_08515) 1612199..1613455 + 1257 WP_265631682.1 ISL3 family transposase -
OQG81_RS08520 (OQG81_08520) 1613498..1613689 - 192 WP_024381035.1 hypothetical protein -
OQG81_RS08525 (OQG81_08525) 1613778..1614050 - 273 WP_024381592.1 DUF3884 family protein -
OQG81_RS08530 (OQG81_08530) 1614079..1615395 - 1317 WP_265644189.1 glycosyltransferase family 2 protein -
OQG81_RS08535 (OQG81_08535) 1615517..1615744 - 228 WP_024381594.1 hypothetical protein -
OQG81_RS08540 (OQG81_08540) 1615987..1616580 - 594 WP_024381595.1 PBECR4 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage erm(B) / aph(3')-III / ant(6)-Ia - 1601795..1633401 31606
- inside IScluster/Tn erm(B) / aph(3')-III / ant(6)-Ia - 1603273..1618482 15209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T265727 WP_000233000.1 NZ_CP113440:c1611591-1610722 [Streptococcus macedonicus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT265727 WP_000205227.1 NZ_CP113440:c1611830-1611606 [Streptococcus macedonicus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References