Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 1521059..1522302 | Replicon | chromosome |
| Accession | NZ_CP113440 | ||
| Organism | Streptococcus macedonicus strain E37 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | OQG81_RS08030 | Protein ID | WP_001235242.1 |
| Coordinates | 1521059..1521826 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | OQG81_RS08035 | Protein ID | WP_000578719.1 |
| Coordinates | 1521826..1522302 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OQG81_RS08015 (OQG81_08015) | 1517447..1517812 | - | 366 | WP_000431640.1 | MobC family plasmid mobilization relaxosome protein | - |
| OQG81_RS08020 (OQG81_08020) | 1517815..1518177 | - | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| OQG81_RS08025 (OQG81_08025) | 1518515..1521058 | - | 2544 | WP_000601012.1 | AAA family ATPase | - |
| OQG81_RS08030 (OQG81_08030) | 1521059..1521826 | - | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| OQG81_RS08035 (OQG81_08035) | 1521826..1522302 | - | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| OQG81_RS08040 (OQG81_08040) | 1522372..1522662 | - | 291 | WP_000667951.1 | hypothetical protein | - |
| OQG81_RS08045 (OQG81_08045) | 1522713..1523102 | - | 390 | WP_000048066.1 | DUF5945 family protein | - |
| OQG81_RS08050 (OQG81_08050) | 1523099..1523326 | - | 228 | WP_000110922.1 | DUF5965 family protein | - |
| OQG81_RS08055 (OQG81_08055) | 1523354..1524454 | - | 1101 | WP_265644121.1 | toprim domain-containing protein | - |
| OQG81_RS08060 (OQG81_08060) | 1524494..1525132 | - | 639 | WP_044981403.1 | hypothetical protein | - |
| OQG81_RS08065 (OQG81_08065) | 1525335..1527149 | - | 1815 | WP_044981401.1 | DUF2075 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(B) / tet(O) | - | 1362892..1598389 | 235497 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T265725 WP_001235242.1 NZ_CP113440:c1521826-1521059 [Streptococcus macedonicus]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT265725 WP_000578719.1 NZ_CP113440:c1522302-1521826 [Streptococcus macedonicus]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|