Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 68513..70050 Replicon chromosome
Accession NZ_CP113439
Organism Legionella pneumophila strain PATHC002

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OXA86_RS00335 Protein ID WP_014840729.1
Coordinates 68513..69811 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OXA86_RS00340 Protein ID WP_014840730.1
Coordinates 69811..70050 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA86_RS00310 (OXA86_00310) 64070..65317 + 1248 WP_014840725.1 SdbB protein (substrate of the Dot/Icm system) -
OXA86_RS00315 (OXA86_00315) 65614..66018 - 405 WP_044496899.1 MerR family transcriptional regulator -
OXA86_RS00320 (OXA86_00320) 66088..66831 + 744 WP_014840727.1 glutaredoxin family protein -
OXA86_RS00325 (OXA86_00325) 67031..68122 + 1092 WP_027220325.1 hypothetical protein -
OXA86_RS00330 (OXA86_00330) 68173..68482 + 310 Protein_65 integrase -
OXA86_RS00335 (OXA86_00335) 68513..69811 - 1299 WP_014840729.1 type II toxin-antitoxin system HipA family toxin Toxin
OXA86_RS00340 (OXA86_00340) 69811..70050 - 240 WP_014840730.1 helix-turn-helix domain-containing protein Antitoxin
OXA86_RS00345 (OXA86_00345) 70144..70374 + 231 Protein_68 hypothetical protein -
OXA86_RS00350 (OXA86_00350) 70684..71049 + 366 WP_044496898.1 TraK family protein -
OXA86_RS00355 (OXA86_00355) 71417..72436 + 1020 WP_044496897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 49434.63 Da        Isoelectric Point: 7.7618

>T265723 WP_014840729.1 NZ_CP113439:c69811-68513 [Legionella pneumophila]
MRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQRFSGEVVYNFFDNLLPDNPQIRARIQARFQ
AKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTAFL
YYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLEVAKSKILQFEDEKVLVVERFDRKWSRD
NRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQPQG
GYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNSHYKIDGIQKRHFIETAKYVQYSKIKAAQIFEQVIDRIDSAID
EVSTQLPNHFPEKIADPIFKGMRAFKERMIST

Download         Length: 1299 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9096.40 Da        Isoelectric Point: 5.0774

>AT265723 WP_014840730.1 NZ_CP113439:c70050-69811 [Legionella pneumophila]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEEIEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References