26572

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 373380..374168 Replicon chromosome
Accession NC_017333
Organism Staphylococcus aureus subsp. aureus ST398

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SAPIG_RS01680 Protein ID WP_000525004.1
Coordinates 373380..373841 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAPIG_RS01685 Protein ID WP_000333630.1
Coordinates 373854..374168 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAPIG_RS01655 368447..370381 + 1935 Protein_325 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
SAPIG_RS01660 370475..371680 - 1206 WP_000264185.1 site-specific integrase -
SAPIG_RS01665 371791..372405 + 615 WP_000191464.1 hypothetical protein -
SAPIG_RS01670 372402..372548 - 147 WP_001795334.1 hypothetical protein -
SAPIG_RS01675 372778..373362 - 585 WP_000825948.1 hypothetical protein -
SAPIG_RS01680 373380..373841 - 462 WP_000525004.1 hypothetical protein Toxin
SAPIG_RS01685 373854..374168 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SAPIG_RS01690 374320..374556 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
SAPIG_RS01695 374570..375346 + 777 WP_001148544.1 Rha family transcriptional regulator -
SAPIG_RS01700 375374..375517 + 144 WP_000939498.1 hypothetical protein -
SAPIG_RS01705 375507..375716 - 210 WP_000642492.1 hypothetical protein -
SAPIG_RS01710 375772..376017 + 246 WP_001025401.1 DUF2829 domain-containing protein -
SAPIG_RS01715 375986..376351 - 366 WP_001128433.1 hypothetical protein -
SAPIG_RS01720 376406..376620 + 215 Protein_338 hypothetical protein -
SAPIG_RS01725 376645..376908 + 264 WP_001124158.1 helix-turn-helix domain-containing protein -
SAPIG_RS01730 376921..377082 + 162 WP_001285954.1 DUF1270 domain-containing protein -
SAPIG_RS01735 377161..377484 + 324 WP_000174994.1 hypothetical protein -
SAPIG_RS01740 377499..377861 + 363 WP_000985976.1 hypothetical protein -
SAPIG_RS01745 377858..379024 + 1167 WP_000762523.1 DUF2800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 370475..417309 46834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T26572 WP_000525004.1 NC_017333:c373841-373380 [Staphylococcus aureus subsp. aureus ST398]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T26572 NC_017333:c373841-373380 [Staphylococcus aureus subsp. aureus ST398]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT26572 WP_000333630.1 NC_017333:c374168-373854 [Staphylococcus aureus subsp. aureus ST398]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT26572 NC_017333:c374168-373854 [Staphylococcus aureus subsp. aureus ST398]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References