Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2341674..2342649 Replicon chromosome
Accession NZ_CP113428
Organism Bacillus cereus strain NW6

Toxin (Protein)


Gene name spoIISA Uniprot ID C3GJ28
Locus tag OU819_RS12060 Protein ID WP_003297560.1
Coordinates 2341674..2342411 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag OU819_RS12065 Protein ID WP_000588712.1
Coordinates 2342524..2342649 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU819_RS12030 (OU819_12030) 2336749..2337459 + 711 WP_000787475.1 class I SAM-dependent methyltransferase -
OU819_RS12035 (OU819_12035) 2337579..2337986 + 408 WP_000072479.1 VOC family protein -
OU819_RS12040 (OU819_12040) 2338092..2338184 + 93 Protein_2288 methyltransferase -
OU819_RS12045 (OU819_12045) 2338306..2339991 - 1686 WP_267999198.1 alpha-keto acid decarboxylase family protein -
OU819_RS12050 (OU819_12050) 2340098..2340580 + 483 WP_088016051.1 MarR family winged helix-turn-helix transcriptional regulator -
OU819_RS12055 (OU819_12055) 2340748..2341485 + 738 WP_000594156.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OU819_RS12060 (OU819_12060) 2341674..2342411 + 738 WP_003297560.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OU819_RS12065 (OU819_12065) 2342524..2342649 + 126 WP_000588712.1 hypothetical protein Antitoxin
OU819_RS12070 (OU819_12070) 2342726..2342902 + 177 WP_088016052.1 stage II sporulation protein SB -
OU819_RS12075 (OU819_12075) 2342946..2343221 - 276 WP_088016053.1 hypothetical protein -
OU819_RS12080 (OU819_12080) 2343502..2343739 - 238 Protein_2296 hypothetical protein -
OU819_RS12085 (OU819_12085) 2343876..2344001 + 126 WP_000694311.1 hypothetical protein -
OU819_RS12090 (OU819_12090) 2344078..2344254 + 177 WP_000808045.1 stage II sporulation protein SB -
OU819_RS12095 (OU819_12095) 2344398..2345867 + 1470 WP_001983236.1 beta-Ala-His dipeptidase -
OU819_RS12100 (OU819_12100) 2346431..2346901 - 471 WP_088016055.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.07 Da        Isoelectric Point: 8.2672

>T265705 WP_003297560.1 NZ_CP113428:2341674-2342411 [Bacillus cereus]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT265705 WP_000588712.1 NZ_CP113428:2342524-2342649 [Bacillus cereus]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9EK80

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References