Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4246753..4247534 Replicon chromosome
Accession NZ_CP113364
Organism Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag OU685_RS20735 Protein ID WP_000625911.1
Coordinates 4246753..4247244 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag OU685_RS20740 Protein ID WP_001271379.1
Coordinates 4247241..4247534 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU685_RS20710 (4241887) 4241887..4244325 - 2439 WP_017441226.1 F4 (K88) fimbrial usher FaeD -
OU685_RS20715 (4244335) 4244335..4244874 - 540 WP_000721295.1 type 1 fimbrial protein -
OU685_RS20720 (4244909) 4244909..4245193 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
OU685_RS20725 (4245787) 4245787..4246044 + 258 WP_001112996.1 hypothetical protein -
OU685_RS20730 (4246290) 4246290..4246538 - 249 Protein_4051 IS481 family transposase -
OU685_RS20735 (4246753) 4246753..4247244 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
OU685_RS20740 (4247241) 4247241..4247534 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
OU685_RS20745 (4247852) 4247852..4248073 + 222 WP_001595143.1 hypothetical protein -
OU685_RS20750 (4248339) 4248339..4249214 + 876 WP_017441228.1 AraC family transcriptional regulator -
OU685_RS20755 (4249211) 4249211..4249498 + 288 WP_072103482.1 transcriptional regulator RtsB -
OU685_RS20760 (4249505) 4249505..4249672 - 168 WP_071527476.1 ATP-binding cassette domain-containing protein -
OU685_RS20765 (4249692) 4249692..4249791 + 100 Protein_4058 hypothetical protein -
OU685_RS20770 (4249839) 4249839..4250033 + 195 WP_223195369.1 hypothetical protein -
OU685_RS20775 (4250327) 4250327..4251232 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4235143..4249498 14355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T265699 WP_000625911.1 NZ_CP113364:c4247244-4246753 [Salmonella enterica subsp. enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT265699 WP_001271379.1 NZ_CP113364:c4247534-4247241 [Salmonella enterica subsp. enterica]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References