Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4102074..4102717 Replicon chromosome
Accession NZ_CP113364
Organism Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag OU685_RS19995 Protein ID WP_017441191.1
Coordinates 4102301..4102717 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag OU685_RS19990 Protein ID WP_001261294.1
Coordinates 4102074..4102304 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU685_RS19980 (4099088) 4099088..4101226 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
OU685_RS19985 (4101443) 4101443..4101907 + 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OU685_RS19990 (4102074) 4102074..4102304 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OU685_RS19995 (4102301) 4102301..4102717 + 417 WP_017441191.1 type II toxin-antitoxin system VapC family toxin Toxin
OU685_RS20000 (4102778) 4102778..4104691 - 1914 WP_023242878.1 BglG family transcription antiterminator -
OU685_RS20005 (4104708) 4104708..4105448 - 741 WP_023229489.1 KDGP aldolase family protein -
OU685_RS20010 (4105445) 4105445..4106563 - 1119 WP_001139194.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OU685_RS20015 (4106547) 4106547..4107680 - 1134 WP_017441192.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15163.55 Da        Isoelectric Point: 8.1381

>T265698 WP_017441191.1 NZ_CP113364:4102301-4102717 [Salmonella enterica subsp. enterica]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAVGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT265698 WP_001261294.1 NZ_CP113364:4102074-4102304 [Salmonella enterica subsp. enterica]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References