Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3399359..3399979 Replicon chromosome
Accession NZ_CP113364
Organism Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OU685_RS16715 Protein ID WP_001280991.1
Coordinates 3399761..3399979 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OU685_RS16710 Protein ID WP_000344807.1
Coordinates 3399359..3399733 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU685_RS16700 (3394498) 3394498..3395691 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OU685_RS16705 (3395714) 3395714..3398863 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OU685_RS16710 (3399359) 3399359..3399733 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OU685_RS16715 (3399761) 3399761..3399979 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OU685_RS16720 (3400158) 3400158..3400709 + 552 WP_001278793.1 maltose O-acetyltransferase -
OU685_RS16725 (3400825) 3400825..3401295 + 471 WP_000136183.1 YlaC family protein -
OU685_RS16730 (3401351) 3401351..3401491 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OU685_RS16735 (3401497) 3401497..3401757 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OU685_RS16740 (3401982) 3401982..3403532 + 1551 WP_000213140.1 EAL domain-containing protein -
OU685_RS16750 (3403763) 3403763..3404152 + 390 WP_000961285.1 MGMT family protein -
OU685_RS16755 (3404185) 3404185..3404754 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T265690 WP_001280991.1 NZ_CP113364:3399761-3399979 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT265690 WP_000344807.1 NZ_CP113364:3399359-3399733 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References