265689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2366456..2366978 Replicon chromosome
Accession NZ_CP113364
Organism Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag OU685_RS11605 Protein ID WP_000221345.1
Coordinates 2366694..2366978 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OU685_RS11600 Protein ID WP_000885424.1
Coordinates 2366456..2366704 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU685_RS11570 (2361999) 2361999..2362779 + 781 Protein_2259 helix-turn-helix domain-containing protein -
OU685_RS11575 (2362781) 2362781..2363689 - 909 WP_077906523.1 hypothetical protein -
OU685_RS11580 (2363962) 2363962..2364294 - 333 WP_017441352.1 DUF1493 family protein -
OU685_RS11585 (2364817) 2364817..2364933 - 117 Protein_2262 IS110 family transposase -
OU685_RS11590 (2365298) 2365298..2365687 + 390 WP_017441353.1 hypothetical protein -
OU685_RS11595 (2365690) 2365690..2366043 + 354 WP_000418733.1 hypothetical protein -
OU685_RS11600 (2366456) 2366456..2366704 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OU685_RS11605 (2366694) 2366694..2366978 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OU685_RS11610 (2367149) 2367149..2367538 + 390 WP_001652798.1 RidA family protein -
OU685_RS11615 (2367596) 2367596..2368669 - 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OU685_RS11620 (2368862) 2368862..2369350 - 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
OU685_RS11625 (2369395) 2369395..2370903 + 1509 WP_017441357.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2357250..2373760 16510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T265689 WP_000221345.1 NZ_CP113364:2366694-2366978 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT265689 WP_000885424.1 NZ_CP113364:2366456-2366704 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References