Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 967633..968447 Replicon chromosome
Accession NZ_CP113364
Organism Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0Q3Z8
Locus tag OU685_RS04645 Protein ID WP_017441137.1
Coordinates 967633..968160 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A418Z520
Locus tag OU685_RS04650 Protein ID WP_017441138.1
Coordinates 968157..968447 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU685_RS04615 (964006) 964006..964404 + 399 Protein_902 cytoplasmic protein -
OU685_RS04620 (964595) 964595..964834 + 240 Protein_903 hypothetical protein -
OU685_RS04625 (964991) 964991..965659 + 669 WP_000445914.1 hypothetical protein -
OU685_RS04630 (965686) 965686..966180 + 495 WP_000424947.1 hypothetical protein -
OU685_RS04635 (966351) 966351..967007 - 657 WP_017441135.1 protein-serine/threonine phosphatase -
OU685_RS04640 (967345) 967345..967560 + 216 Protein_907 IS5/IS1182 family transposase -
OU685_RS04645 (967633) 967633..968160 - 528 WP_017441137.1 GNAT family N-acetyltransferase Toxin
OU685_RS04650 (968157) 968157..968447 - 291 WP_017441138.1 DUF1778 domain-containing protein Antitoxin
OU685_RS04655 (968717) 968717..968917 - 201 Protein_910 IS3 family transposase -
OU685_RS04660 (969158) 969158..969484 + 327 WP_000393295.1 hypothetical protein -
OU685_RS04665 (969757) 969757..970104 - 348 WP_001555786.1 DUF1493 family protein -
OU685_RS04670 (970089) 970089..970538 - 450 WP_017441139.1 hypothetical protein -
OU685_RS04675 (970970) 970970..971413 - 444 WP_017441140.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OU685_RS04680 (971869) 971869..972519 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 967420..977832 10412
- flank IS/Tn - - 967420..967560 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19035.89 Da        Isoelectric Point: 9.6420

>T265683 WP_017441137.1 NZ_CP113364:c968160-967633 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SLKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.55 Da        Isoelectric Point: 8.5957

>AT265683 WP_017441138.1 NZ_CP113364:c968447-968157 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFARPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0Q3Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A418Z520

References