Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 286210..287001 Replicon chromosome
Accession NZ_CP113364
Organism Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag OU685_RS01325 Protein ID WP_000369560.1
Coordinates 286483..287001 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag OU685_RS01320 Protein ID WP_001275017.1
Coordinates 286210..286479 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU685_RS01300 (281791) 281791..282459 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
OU685_RS01305 (282452) 282452..283507 + 1056 WP_001081707.1 permease-like cell division protein FtsX -
OU685_RS01310 (283753) 283753..284607 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
OU685_RS01315 (284929) 284929..286032 + 1104 WP_001528146.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
OU685_RS01320 (286210) 286210..286479 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
OU685_RS01325 (286483) 286483..287001 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
OU685_RS01330 (286998) 286998..287381 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
OU685_RS01335 (287803) 287803..288912 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
OU685_RS01340 (288972) 288972..289898 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
OU685_RS01345 (289895) 289895..291172 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
OU685_RS01350 (291169) 291169..291936 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T265679 WP_000369560.1 NZ_CP113364:286483-287001 [Salmonella enterica subsp. enterica]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT265679 WP_001275017.1 NZ_CP113364:286210-286479 [Salmonella enterica subsp. enterica]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References