265676

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1010780..1011278 Replicon chromosome
Accession NZ_CP113267
Organism Streptococcus pneumoniae strain BC2

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag OTB22_RS05090 Protein ID WP_001823540.1
Coordinates 1010780..1011034 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag OTB22_RS05095 Protein ID WP_000208080.1
Coordinates 1011036..1011278 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTB22_RS05075 (OTB22_05080) 1006053..1008521 - 2469 WP_001152989.1 DNA gyrase subunit A -
OTB22_RS05080 (OTB22_05085) 1008715..1009701 + 987 WP_000204727.1 L-lactate dehydrogenase -
OTB22_RS05085 (OTB22_05090) 1009957..1010733 - 777 WP_001865265.1 ion channel -
OTB22_RS05090 (OTB22_05095) 1010780..1011034 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OTB22_RS05095 (OTB22_05100) 1011036..1011278 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
OTB22_RS05100 (OTB22_05105) 1011369..1012178 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
OTB22_RS05105 (OTB22_05110) 1012180..1013529 - 1350 WP_050251702.1 cell wall metabolism sensor histidine kinase VicK -
OTB22_RS05110 (OTB22_05115) 1013522..1014226 - 705 WP_000722076.1 response regulator YycF -
OTB22_RS05115 (OTB22_05120) 1014281..1015456 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
OTB22_RS05120 (OTB22_05125) 1015553..1015678 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T265676 WP_001823540.1 NZ_CP113267:c1011034-1010780 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT265676 WP_000208080.1 NZ_CP113267:c1011278-1011036 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References