Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 405184..405852 Replicon chromosome
Accession NZ_CP113267
Organism Streptococcus pneumoniae strain BC2

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag OTB22_RS02130 Protein ID WP_001132285.1
Coordinates 405184..405363 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag OTB22_RS02135 Protein ID WP_000961810.1
Coordinates 405400..405852 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTB22_RS02105 (OTB22_02110) 401053..402372 + 1320 WP_061761994.1 glycoside hydrolase family 32 protein -
OTB22_RS02115 (OTB22_02120) 402923..404194 - 1272 WP_001113212.1 replication-associated recombination protein A -
OTB22_RS02120 (OTB22_02125) 404464..404703 + 240 WP_000818078.1 hypothetical protein -
OTB22_RS02125 (OTB22_02130) 404868..405047 + 180 WP_001048906.1 hypothetical protein -
OTB22_RS02130 (OTB22_02135) 405184..405363 + 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
OTB22_RS02135 (OTB22_02140) 405400..405852 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OTB22_RS02140 (OTB22_02145) 406143..406613 + 471 WP_023396411.1 DUF3013 family protein -
OTB22_RS02145 (OTB22_02150) 406669..407211 + 543 WP_000891117.1 hypothetical protein -
OTB22_RS02150 (OTB22_02155) 407261..407695 + 435 WP_000421871.1 NUDIX hydrolase -
OTB22_RS02155 (OTB22_02160) 407692..408165 + 474 WP_023396410.1 GNAT family N-acetyltransferase -
OTB22_RS02160 (OTB22_02165) 408303..409253 + 951 WP_023396409.1 50S ribosomal protein L11 methyltransferase -
OTB22_RS02165 (OTB22_02170) 409255..409998 + 744 WP_023396408.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T265675 WP_001132285.1 NZ_CP113267:405184-405363 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT265675 WP_000961810.1 NZ_CP113267:405400-405852 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References