Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 793648..794316 Replicon chromosome
Accession NZ_CP113266
Organism Streptococcus pneumoniae strain BC1

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag OS912_RS03890 Protein ID WP_001132282.1
Coordinates 794137..794316 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag OS912_RS03885 Protein ID WP_000961810.1
Coordinates 793648..794100 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS912_RS03860 (OS912_03865) 789538..790281 - 744 WP_001188182.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
OS912_RS03865 (OS912_03870) 790283..791233 - 951 WP_268233018.1 50S ribosomal protein L11 methyltransferase -
OS912_RS03870 (OS912_03875) 791371..791799 - 429 WP_000418168.1 NUDIX hydrolase -
OS912_RS03875 (OS912_03880) 791780..792868 - 1089 WP_000719700.1 site-2 protease family protein -
OS912_RS03880 (OS912_03885) 792887..793357 - 471 WP_000257084.1 DUF3013 family protein -
OS912_RS03885 (OS912_03890) 793648..794100 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OS912_RS03890 (OS912_03895) 794137..794316 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
OS912_RS03895 (OS912_03900) 794453..794632 - 180 WP_001048906.1 hypothetical protein -
OS912_RS03900 (OS912_03905) 794836..795036 - 201 WP_000818077.1 hypothetical protein -
OS912_RS03905 (OS912_03910) 795306..796577 + 1272 WP_001113212.1 replication-associated recombination protein A -
OS912_RS03915 (OS912_03920) 797123..798442 - 1320 WP_050102825.1 glycoside hydrolase family 32 protein -
OS912_RS03920 (OS912_03925) 798452..799297 - 846 WP_000819519.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T265674 WP_001132282.1 NZ_CP113266:c794316-794137 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT265674 WP_000961810.1 NZ_CP113266:c794100-793648 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References