Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 308901..309399 Replicon chromosome
Accession NZ_CP113266
Organism Streptococcus pneumoniae strain BC1

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag OS912_RS01500 Protein ID WP_001809704.1
Coordinates 308901..309155 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag OS912_RS01505 Protein ID WP_000208080.1
Coordinates 309157..309399 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS912_RS01495 (OS912_01500) 306940..308826 - 1887 WP_000150984.1 Eco57I restriction-modification methylase domain-containing protein -
OS912_RS01500 (OS912_01505) 308901..309155 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OS912_RS01505 (OS912_01510) 309157..309399 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
OS912_RS01510 (OS912_01515) 309490..310299 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
OS912_RS01515 (OS912_01520) 310301..311650 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
OS912_RS01520 (OS912_01525) 311643..312347 - 705 WP_000722076.1 response regulator YycF -
OS912_RS01525 (OS912_01530) 312402..313577 - 1176 WP_050202456.1 A/G-specific adenine glycosylase -
OS912_RS01530 (OS912_01535) 313674..313799 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T265672 WP_001809704.1 NZ_CP113266:c309155-308901 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT265672 WP_000208080.1 NZ_CP113266:c309399-309157 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References