Detailed information of TA system TA265671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 110444..111678
• Replicon: chromosome
• Accession: NZ_CP113266
• Organism: Streptococcus pneumoniae strain BC1

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: A0A1B1IH38
• Locus tag: OS912_RS00600
• Protein ID: WP_061702636.1
• Coordinates: 110920..111678 (+)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: OS912_RS00595
• Protein ID: WP_061757087.1
• Coordinates: 110444..110920 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OS912_RS00555 (OS912_00560)	106699..106983	+	285	WP_000969635.1	DUF5962 family protein	-
OS912_RS00560 (OS912_00565)	106997..107293	+	297	WP_024478354.1	DUF5966 family protein	-
OS912_RS00565 (OS912_00570)	107307..107504	-	198	WP_002876112.1	hypothetical protein	-
OS912_RS00570 (OS912_00575)	107664..108305	+	642	WP_000933083.1	hypothetical protein	-
OS912_RS00575 (OS912_00580)	108315..109400	+	1086	WP_061702634.1	DUF3991 domain-containing protein	-
OS912_RS00580 (OS912_00585)	109451..109684	+	234	WP_000152419.1	DUF5965 family protein	-
OS912_RS00585 (OS912_00590)	109681..110064	+	384	WP_261196670.1	DUF5945 family protein	-
OS912_RS00590 (OS912_00595)	110102..110374	+	273	WP_061757088.1	hypothetical protein	-
OS912_RS00595 (OS912_00600)	110444..110920	+	477	WP_061757087.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
OS912_RS00600 (OS912_00605)	110920..111678	+	759	WP_061702636.1	type II toxin-antitoxin system toxin PezT	Toxin
OS912_RS00605 (OS912_00610)	111828..113221	+	1394	Protein_119	IS3 family transposase	-
OS912_RS00610 (OS912_00615)	113286..114577	+	1292	Protein_120	IS110 family transposase	-
OS912_RS00615 (OS912_00620)	114969..115187	+	219	WP_061757291.1	helix-turn-helix transcriptional regulator	-
OS912_RS00620 (OS912_00625)	115184..115837	+	654	WP_061767025.1	PIG-L family deacetylase	-
OS912_RS00625 (OS912_00630)	115909..116673	+	765	WP_061767026.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	-	55050..174073	119023

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 28951.83 Da
• Isoelectric Point: 6.9817

>T265671 WP_061702636.1 NZ_CP113266:110920-111678 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALERNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTN

Nucleotide

• Length: 759 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18257.74 Da
• Isoelectric Point: 4.4188

>AT265671 WP_061757087.1 NZ_CP113266:110444-110920 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDIQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A1B1IH38