Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2503735..2504428 Replicon chromosome
Accession NZ_CP113257
Organism Stutzerimonas frequens strain TF18

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag OSV15_RS12200 Protein ID WP_003151133.1
Coordinates 2503735..2504112 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag OSV15_RS12205 Protein ID WP_001172026.1
Coordinates 2504093..2504428 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSV15_RS12190 (OSV15_12190) 2499928..2502957 - 3030 WP_010799689.1 Tn3 family transposase -
OSV15_RS12195 (OSV15_12195) 2502941..2503543 - 603 WP_010465829.1 recombinase family protein -
OSV15_RS12200 (OSV15_12200) 2503735..2504112 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSV15_RS12205 (OSV15_12205) 2504093..2504428 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
OSV15_RS12210 (OSV15_12210) 2504443..2504778 + 336 WP_000741275.1 hypothetical protein -
OSV15_RS12215 (OSV15_12215) 2504802..2505128 + 327 WP_000091614.1 hypothetical protein -
OSV15_RS12220 (OSV15_12220) 2505144..2505485 + 342 WP_025999701.1 hypothetical protein -
OSV15_RS12225 (OSV15_12225) 2505786..2506880 - 1095 WP_125882712.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T265667 WP_003151133.1 NZ_CP113257:2503735-2504112 [Stutzerimonas frequens]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT265667 WP_001172026.1 NZ_CP113257:2504093-2504428 [Stutzerimonas frequens]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References