Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6109657..6110162 Replicon chromosome
Accession NZ_CP113246
Organism Pseudomonas aeruginosa strain SMC4386

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag OUY23_RS28255 Protein ID WP_003083773.1
Coordinates 6109881..6110162 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag OUY23_RS28250 Protein ID WP_003083775.1
Coordinates 6109657..6109884 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUY23_RS28225 (OUY23_28225) 6104675..6106168 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
OUY23_RS28230 (OUY23_28230) 6106337..6107764 + 1428 WP_003083784.1 GABA permease -
OUY23_RS28235 (OUY23_28235) 6107846..6108187 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
OUY23_RS28240 (OUY23_28240) 6108260..6108760 - 501 WP_003112629.1 LEA type 2 family protein -
OUY23_RS28245 (OUY23_28245) 6108861..6109481 + 621 WP_003101226.1 hypothetical protein -
OUY23_RS28250 (OUY23_28250) 6109657..6109884 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
OUY23_RS28255 (OUY23_28255) 6109881..6110162 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
OUY23_RS28260 (OUY23_28260) 6110462..6111370 + 909 WP_003083769.1 LysR family transcriptional regulator -
OUY23_RS28265 (OUY23_28265) 6111402..6111812 - 411 WP_003101225.1 aegerolysin family protein -
OUY23_RS28270 (OUY23_28270) 6111992..6112726 - 735 WP_003117208.1 GntR family transcriptional regulator -
OUY23_RS28275 (OUY23_28275) 6112827..6113513 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
OUY23_RS28280 (OUY23_28280) 6113562..6114911 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T265658 WP_003083773.1 NZ_CP113246:6109881-6110162 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT265658 WP_003083775.1 NZ_CP113246:6109657-6109884 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References