Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4429860..4431368 Replicon chromosome
Accession NZ_CP113246
Organism Pseudomonas aeruginosa strain SMC4386

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag OUY23_RS20425 Protein ID WP_003119682.1
Coordinates 4430781..4431368 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag OUY23_RS20420 Protein ID WP_003119683.1
Coordinates 4429860..4430714 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUY23_RS20405 (OUY23_20405) 4425279..4425488 + 210 WP_003115568.1 cold-shock protein -
OUY23_RS20410 (OUY23_20410) 4425549..4427423 - 1875 WP_003117607.1 MFS transporter -
OUY23_RS20415 (OUY23_20415) 4427598..4429763 - 2166 WP_058876957.1 TonB-dependent receptor family protein -
OUY23_RS20420 (OUY23_20420) 4429860..4430714 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
OUY23_RS20425 (OUY23_20425) 4430781..4431368 - 588 WP_003119682.1 GNAT family protein Toxin
OUY23_RS20430 (OUY23_20430) 4431634..4435113 + 3480 WP_058876958.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T265657 WP_003119682.1 NZ_CP113246:c4431368-4430781 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT265657 WP_003119683.1 NZ_CP113246:c4430714-4429860 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References