Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2804351..2805572 Replicon chromosome
Accession NZ_CP113246
Organism Pseudomonas aeruginosa strain SMC4386

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag OUY23_RS13045 Protein ID WP_003102740.1
Coordinates 2804351..2804929 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OUY23_RS13050 Protein ID WP_003088112.1
Coordinates 2805018..2805572 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUY23_RS13030 (OUY23_13030) 2799627..2800904 + 1278 WP_058877012.1 TolC family protein -
OUY23_RS13035 (OUY23_13035) 2800894..2803065 + 2172 WP_058877011.1 type I secretion system permease/ATPase -
OUY23_RS13040 (OUY23_13040) 2803055..2804242 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
OUY23_RS13045 (OUY23_13045) 2804351..2804929 - 579 WP_003102740.1 HD domain-containing protein Toxin
OUY23_RS13050 (OUY23_13050) 2805018..2805572 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
OUY23_RS13055 (OUY23_13055) 2805730..2807925 - 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
OUY23_RS13060 (OUY23_13060) 2807930..2808391 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
OUY23_RS13065 (OUY23_13065) 2808722..2809045 + 324 WP_003102734.1 multidrug efflux SMR transporter -
OUY23_RS13070 (OUY23_13070) 2809058..2809456 + 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
OUY23_RS13075 (OUY23_13075) 2809453..2810004 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T265656 WP_003102740.1 NZ_CP113246:c2804929-2804351 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT265656 WP_003088112.1 NZ_CP113246:c2805572-2805018 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References