Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1869406..1870664 Replicon chromosome
Accession NZ_CP113246
Organism Pseudomonas aeruginosa strain SMC4386

Toxin (Protein)


Gene name - Uniprot ID A0A0H2Z7F3
Locus tag OUY23_RS08670 Protein ID WP_003140635.1
Coordinates 1869909..1870664 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag OUY23_RS08665 Protein ID WP_003086329.1
Coordinates 1869406..1869774 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUY23_RS08645 (OUY23_08645) 1865569..1865844 + 276 WP_172655204.1 zinc ribbon domain-containing protein -
OUY23_RS08650 (OUY23_08650) 1865847..1866323 - 477 WP_029611026.1 hypothetical protein -
OUY23_RS08655 (OUY23_08655) 1866402..1867991 + 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
OUY23_RS08660 (OUY23_08660) 1868047..1869333 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
OUY23_RS08665 (OUY23_08665) 1869406..1869774 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
OUY23_RS08670 (OUY23_08670) 1869909..1870664 + 756 WP_003140635.1 RES family NAD+ phosphorylase Toxin
OUY23_RS08675 (OUY23_08675) 1871434..1872795 + 1362 WP_003081943.1 DNA recombination protein RmuC -
OUY23_RS08680 (OUY23_08680) 1872950..1875493 - 2544 WP_079753647.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28220.34 Da        Isoelectric Point: 7.7294

>T265655 WP_003140635.1 NZ_CP113246:1869909-1870664 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT265655 WP_003086329.1 NZ_CP113246:1869406-1869774 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z7F3

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References