Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 223718..224484 Replicon chromosome
Accession NZ_CP113242
Organism Vibrio sp. gvc

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag OOK74_RS12635 Protein ID WP_278183482.1
Coordinates 223987..224484 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag OOK74_RS12630 Protein ID WP_274723737.1
Coordinates 223718..223990 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK74_RS12595 219809..220717 - 909 WP_278183512.1 hypothetical protein -
OOK74_RS12600 220919..221500 - 582 WP_278183513.1 hypothetical protein -
OOK74_RS12605 221531..221647 - 117 WP_277206986.1 DUF3265 domain-containing protein -
OOK74_RS12610 221711..221953 + 243 WP_277206988.1 type II toxin-antitoxin system ParD family antitoxin -
OOK74_RS12615 221950..222249 + 300 WP_278183514.1 type II toxin-antitoxin system RelE/ParE family toxin -
OOK74_RS12620 222257..222349 - 93 WP_079857208.1 DUF3265 domain-containing protein -
OOK74_RS12625 222364..222888 - 525 WP_278183515.1 DUF4476 domain-containing protein -
OOK74_RS12630 223718..223990 + 273 WP_274723737.1 DUF1778 domain-containing protein Antitoxin
OOK74_RS12635 223987..224484 + 498 WP_278183482.1 GNAT family N-acetyltransferase Toxin
OOK74_RS12640 224578..225186 - 609 WP_278183516.1 hypothetical protein -
OOK74_RS12645 225217..225309 - 93 WP_278183517.1 DUF3265 domain-containing protein -
OOK74_RS12650 225359..225913 - 555 WP_278183518.1 hypothetical protein -
OOK74_RS12655 226123..226311 - 189 WP_278183519.1 DUF645 family protein -
OOK74_RS12660 226486..226596 - 111 WP_278183590.1 DUF3265 domain-containing protein -
OOK74_RS12665 226593..227504 - 912 WP_278183520.1 HNH endonuclease -
OOK74_RS12670 227539..227631 - 93 WP_079720574.1 DUF3265 domain-containing protein -
OOK74_RS12675 227654..228094 - 441 WP_278183521.1 DUF2513 domain-containing protein -
OOK74_RS12680 228239..228655 - 417 WP_278183522.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron qnrVC4 - 188538..263116 74578
- inside Integron - - 188538..263116 74578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18639.35 Da        Isoelectric Point: 8.8085

>T265652 WP_278183482.1 NZ_CP113242:223987-224484 [Vibrio sp. gvc]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMSSQQAKKDNTRTFVLEDDNNNTHIIGFYTLTMTPIDLKALPDKLQKKHQ
LSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RANLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9821.38 Da        Isoelectric Point: 8.5181

>AT265652 WP_274723737.1 NZ_CP113242:223718-223990 [Vibrio sp. gvc]
MATTLPRITARVDVDTQYLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADALLLMEALDNPATINTKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References