Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1500307..1501083 Replicon chromosome
Accession NZ_CP113231
Organism Staphylococcus aureus strain BIAI 158

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag OSZ57_RS07395 Protein ID WP_000031109.1
Coordinates 1500307..1500459 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OSZ57_RS07400 Protein ID WP_001251224.1
Coordinates 1500484..1501083 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ57_RS07380 (1496226) 1496226..1497047 + 822 WP_000669377.1 RluA family pseudouridine synthase -
OSZ57_RS07385 (1497504) 1497504..1498889 - 1386 WP_000116239.1 class II fumarate hydratase -
OSZ57_RS07390 (1499085) 1499085..1499480 - 396 WP_000901019.1 hypothetical protein -
OSZ57_RS07395 (1500307) 1500307..1500459 - 153 WP_000031109.1 SAS053 family protein Toxin
OSZ57_RS07400 (1500484) 1500484..1501083 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OSZ57_RS07405 (1501242) 1501242..1501712 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OSZ57_RS07410 (1501717) 1501717..1502844 - 1128 WP_000379990.1 tRNA epoxyqueuosine(34) reductase QueG -
OSZ57_RS07415 (1502995) 1502995..1503717 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OSZ57_RS07420 (1503710) 1503710..1505167 - 1458 WP_000649916.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5950.31 Da        Isoelectric Point: 3.9075

>T265639 WP_000031109.1 NZ_CP113231:c1500459-1500307 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265639 WP_001251224.1 NZ_CP113231:c1501083-1500484 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References