265637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 410430..410959 Replicon chromosome
Accession NZ_CP113231
Organism Staphylococcus aureus strain BIAI 158

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX6
Locus tag OSZ57_RS01980 Protein ID WP_001103939.1
Coordinates 410642..410959 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IY59
Locus tag OSZ57_RS01975 Protein ID WP_001058494.1
Coordinates 410430..410639 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ57_RS01940 (406760) 406760..407224 + 465 WP_001085185.1 SsrA-binding protein SmpB -
OSZ57_RS01950 (407787) 407787..408893 - 1107 WP_000149511.1 tyrosine-type recombinase/integrase -
OSZ57_RS01955 (408883) 408883..409686 - 804 WP_000358990.1 helix-turn-helix transcriptional regulator -
OSZ57_RS01960 (409822) 409822..410025 + 204 WP_001045296.1 transcriptional regulator -
OSZ57_RS01965 (410061) 410061..410279 + 219 WP_000163544.1 helix-turn-helix transcriptional regulator -
OSZ57_RS01970 (410291) 410291..410437 + 147 WP_000784885.1 hypothetical protein -
OSZ57_RS01975 (410430) 410430..410639 + 210 WP_001058494.1 hypothetical protein Antitoxin
OSZ57_RS01980 (410642) 410642..410959 + 318 WP_001103939.1 DUF1474 family protein Toxin
OSZ57_RS01985 (411023) 411023..411892 + 870 WP_001002717.1 primase alpha helix C-terminal domain-containing protein -
OSZ57_RS01990 (411909) 411909..413366 + 1458 WP_000390453.1 virulence-associated E family protein -
OSZ57_RS01995 (413667) 413667..414029 + 363 WP_001039170.1 hypothetical protein -
OSZ57_RS02000 (414031) 414031..414315 + 285 WP_000998185.1 hypothetical protein -
OSZ57_RS02005 (414312) 414312..414953 + 642 WP_001019808.1 hypothetical protein -
OSZ57_RS02010 (415200) 415200..415334 + 135 WP_256094151.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12547.17 Da        Isoelectric Point: 5.0161

>T265637 WP_001103939.1 NZ_CP113231:410642-410959 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Download         Length: 318 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8268.31 Da        Isoelectric Point: 4.3718

>AT265637 WP_001058494.1 NZ_CP113231:410430-410639 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX6

Antitoxin

Source ID Structure
AlphaFold DB X5IY59

References