Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 105511..106040 Replicon chromosome
Accession NZ_CP113231
Organism Staphylococcus aureus strain BIAI 158

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OSZ57_RS00515 Protein ID WP_000621175.1
Coordinates 105678..106040 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OSZ57_RS00510 Protein ID WP_000948331.1
Coordinates 105511..105681 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ57_RS00480 (100548) 100548..101108 + 561 WP_001092406.1 K(+)-transporting ATPase subunit C -
OSZ57_RS00485 (101316) 101316..101795 + 480 WP_001287077.1 hypothetical protein -
OSZ57_RS00490 (101788) 101788..103371 + 1584 WP_001294637.1 PH domain-containing protein -
OSZ57_RS00495 (103358) 103358..103849 + 492 WP_001205907.1 PH domain-containing protein -
OSZ57_RS00500 (103853) 103853..104212 + 360 WP_000581199.1 holo-ACP synthase -
OSZ57_RS00505 (104278) 104278..105426 + 1149 WP_001281140.1 alanine racemase -
OSZ57_RS00510 (105511) 105511..105681 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OSZ57_RS00515 (105678) 105678..106040 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OSZ57_RS00520 (106389) 106389..107390 + 1002 WP_042744356.1 PP2C family protein-serine/threonine phosphatase -
OSZ57_RS00525 (107509) 107509..107835 + 327 WP_001052491.1 anti-sigma factor antagonist -
OSZ57_RS00530 (107837) 107837..108316 + 480 WP_001190825.1 anti-sigma B factor RsbW -
OSZ57_RS00535 (108291) 108291..109061 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265636 WP_000621175.1 NZ_CP113231:105678-106040 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp


Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265636 WP_000948331.1 NZ_CP113231:105511-105681 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References