Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 85783..86297 Replicon chromosome
Accession NZ_CP113231
Organism Staphylococcus aureus strain BIAI 158

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag OSZ57_RS00425 Protein ID WP_000581795.1
Coordinates 86088..86297 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag OSZ57_RS00420 Protein ID WP_000138930.1
Coordinates 85783..86076 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ57_RS00400 (81309) 81309..81950 + 642 WP_000483162.1 thiamine phosphate synthase -
OSZ57_RS00405 (82036) 82036..82908 + 873 WP_000725802.1 membrane protein insertase YidC -
OSZ57_RS00410 (83458) 83458..84105 - 648 WP_001187625.1 HD domain-containing protein -
OSZ57_RS00415 (84133) 84133..85617 - 1485 WP_000571562.1 cardiolipin synthase -
OSZ57_RS00420 (85783) 85783..86076 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
OSZ57_RS00425 (86088) 86088..86297 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
OSZ57_RS00430 (86425) 86425..86562 + 138 WP_000828354.1 Lmo0850 family protein -
OSZ57_RS00435 (86826) 86826..88028 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OSZ57_RS00440 (88346) 88346..89416 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
OSZ57_RS00445 (89431) 89431..90789 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T265635 WP_000581795.1 NZ_CP113231:86088-86297 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT265635 WP_000138930.1 NZ_CP113231:85783-86076 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References