Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 6372786..6374043 Replicon chromosome
Accession NZ_CP113230
Organism Pseudomonas aeruginosa strain BIAI 160

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag OSZ60_RS29915 Protein ID WP_023084953.1
Coordinates 6372786..6373541 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag OSZ60_RS29920 Protein ID WP_003086329.1
Coordinates 6373675..6374043 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ60_RS29905 (OSZ60_29905) 6367959..6370502 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
OSZ60_RS29910 (OSZ60_29910) 6370657..6372018 - 1362 WP_003081943.1 DNA recombination protein RmuC -
OSZ60_RS29915 (OSZ60_29915) 6372786..6373541 - 756 WP_023084953.1 RES family NAD+ phosphorylase Toxin
OSZ60_RS29920 (OSZ60_29920) 6373675..6374043 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
OSZ60_RS29925 (OSZ60_29925) 6374116..6375403 - 1288 Protein_5916 FAD-binding oxidoreductase -
OSZ60_RS29930 (OSZ60_29930) 6375459..6377048 - 1590 WP_079384792.1 aldehyde dehydrogenase family protein -
OSZ60_RS29935 (OSZ60_29935) 6377126..6377602 + 477 WP_031675481.1 elongation factor GreAB -
OSZ60_RS29940 (OSZ60_29940) 6377605..6377880 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28310.49 Da        Isoelectric Point: 7.7294

>T265634 WP_023084953.1 NZ_CP113230:c6373541-6372786 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT265634 WP_003086329.1 NZ_CP113230:c6374043-6373675 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References