Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5422083..5423304 Replicon chromosome
Accession NZ_CP113230
Organism Pseudomonas aeruginosa strain BIAI 160

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OSZ60_RS25495 Protein ID WP_003114949.1
Coordinates 5422726..5423304 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OSZ60_RS25490 Protein ID WP_034073312.1
Coordinates 5422083..5422637 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ60_RS25465 (OSZ60_25465) 5417651..5418202 + 552 WP_003132721.1 XRE family transcriptional regulator -
OSZ60_RS25470 (OSZ60_25470) 5418199..5418597 - 399 WP_031756111.1 NADH-quinone oxidoreductase subunit A -
OSZ60_RS25475 (OSZ60_25475) 5418610..5418933 - 324 WP_003102734.1 multidrug efflux SMR transporter -
OSZ60_RS25480 (OSZ60_25480) 5419264..5419725 + 462 WP_003088117.1 (2Fe-2S)-binding protein -
OSZ60_RS25485 (OSZ60_25485) 5419730..5421925 + 2196 WP_016263578.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
OSZ60_RS25490 (OSZ60_25490) 5422083..5422637 + 555 WP_034073312.1 helix-turn-helix transcriptional regulator Antitoxin
OSZ60_RS25495 (OSZ60_25495) 5422726..5423304 + 579 WP_003114949.1 HD domain-containing protein Toxin
OSZ60_RS25500 (OSZ60_25500) 5423412..5424599 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
OSZ60_RS25505 (OSZ60_25505) 5424589..5426760 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
OSZ60_RS25510 (OSZ60_25510) 5426750..5428027 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-61)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T265633 WP_003114949.1 NZ_CP113230:5422726-5423304 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20412.55 Da        Isoelectric Point: 8.1590

>AT265633 WP_034073312.1 NZ_CP113230:5422083-5422637 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLGEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References