Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1578147..1578652 Replicon chromosome
Accession NZ_CP113230
Organism Pseudomonas aeruginosa strain BIAI 160

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag OSZ60_RS07755 Protein ID WP_003083773.1
Coordinates 1578371..1578652 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag OSZ60_RS07750 Protein ID WP_003083775.1
Coordinates 1578147..1578374 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ60_RS07725 (OSZ60_07725) 1573165..1574658 + 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
OSZ60_RS07730 (OSZ60_07730) 1574827..1576254 + 1428 WP_267749919.1 GABA permease -
OSZ60_RS07735 (OSZ60_07735) 1576336..1576677 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
OSZ60_RS07740 (OSZ60_07740) 1576750..1577250 - 501 WP_003112629.1 LEA type 2 family protein -
OSZ60_RS07745 (OSZ60_07745) 1577351..1577971 + 621 WP_003101226.1 hypothetical protein -
OSZ60_RS07750 (OSZ60_07750) 1578147..1578374 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
OSZ60_RS07755 (OSZ60_07755) 1578371..1578652 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
OSZ60_RS07760 (OSZ60_07760) 1578952..1579860 + 909 WP_003083769.1 LysR family transcriptional regulator -
OSZ60_RS07765 (OSZ60_07765) 1579892..1580302 - 411 WP_003101225.1 aegerolysin family protein -
OSZ60_RS07770 (OSZ60_07770) 1580482..1581216 - 735 WP_003117208.1 GntR family transcriptional regulator -
OSZ60_RS07775 (OSZ60_07775) 1581317..1582003 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
OSZ60_RS07780 (OSZ60_07780) 1582052..1583401 - 1350 WP_079279937.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T265629 WP_003083773.1 NZ_CP113230:1578371-1578652 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT265629 WP_003083775.1 NZ_CP113230:1578147-1578374 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References