Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 60180..61090 | Replicon | plasmid pSCLC9-2_2 |
| Accession | NZ_CP113217 | ||
| Organism | Klebsiella pneumoniae strain SCLC9-2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | OT489_RS27220 | Protein ID | WP_004181896.1 |
| Coordinates | 60180..60650 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | OT489_RS27225 | Protein ID | WP_004181895.1 |
| Coordinates | 60647..61090 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OT489_RS27200 (OT489_27200) | 56777..57154 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| OT489_RS27205 (OT489_27205) | 57352..58326 | - | 975 | WP_040222313.1 | hypothetical protein | - |
| OT489_RS27210 (OT489_27210) | 58929..59087 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| OT489_RS27215 (OT489_27215) | 59810..60070 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| OT489_RS27220 (OT489_27220) | 60180..60650 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| OT489_RS27225 (OT489_27225) | 60647..61090 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| OT489_RS27230 (OT489_27230) | 61191..62462 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OT489_RS27235 (OT489_27235) | 62462..62884 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OT489_RS27240 (OT489_27240) | 62970..64457 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| OT489_RS27245 (OT489_27245) | 65149..65718 | - | 570 | Protein_60 | transposase | - |
| OT489_RS27250 (OT489_27250) | 65720..65935 | + | 216 | Protein_61 | IS200/IS605 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(6)-Id / aph(3'')-Ib / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / aph(3')-Ia | - | 1..254258 | 254258 | |
| - | flank | IS/Tn | - | - | 65149..65502 | 353 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T265623 WP_004181896.1 NZ_CP113217:c60650-60180 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT265623 WP_004181895.1 NZ_CP113217:c61090-60647 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |