Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5351930..5352555 Replicon chromosome
Accession NZ_CP113216
Organism Klebsiella pneumoniae strain SCLC9-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag OT489_RS26580 Protein ID WP_004187928.1
Coordinates 5351930..5352313 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OT489_RS26585 Protein ID WP_004150355.1
Coordinates 5352313..5352555 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT489_RS26565 (5349296) 5349296..5350198 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OT489_RS26570 (5350195) 5350195..5350830 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OT489_RS26575 (5350827) 5350827..5351756 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OT489_RS26580 (5351930) 5351930..5352313 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
OT489_RS26585 (5352313) 5352313..5352555 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OT489_RS26590 (5352749) 5352749..5353666 + 918 WP_004187929.1 alpha/beta hydrolase -
OT489_RS26595 (5353680) 5353680..5354621 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OT489_RS26600 (5354666) 5354666..5355103 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OT489_RS26605 (5355100) 5355100..5355960 - 861 WP_004146232.1 virulence factor BrkB family protein -
OT489_RS26610 (5355954) 5355954..5356553 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T265622 WP_004187928.1 NZ_CP113216:c5352313-5351930 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT265622 WP_004150355.1 NZ_CP113216:c5352555-5352313 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References