Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4862300..4862816 Replicon chromosome
Accession NZ_CP113216
Organism Klebsiella pneumoniae strain SCLC9-2

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag OT489_RS24255 Protein ID WP_004192395.1
Coordinates 4862300..4862584 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag OT489_RS24260 Protein ID WP_004192397.1
Coordinates 4862574..4862816 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT489_RS24230 (4857717) 4857717..4857980 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OT489_RS24235 (4858110) 4858110..4858283 + 174 WP_002886906.1 hypothetical protein -
OT489_RS24240 (4858286) 4858286..4859029 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT489_RS24245 (4859386) 4859386..4861524 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT489_RS24250 (4861832) 4861832..4862296 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT489_RS24255 (4862300) 4862300..4862584 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT489_RS24260 (4862574) 4862574..4862816 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT489_RS24265 (4862894) 4862894..4864804 - 1911 WP_004152270.1 PRD domain-containing protein -
OT489_RS24270 (4864827) 4864827..4865981 - 1155 WP_004178372.1 lactonase family protein -
OT489_RS24275 (4866048) 4866048..4866788 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T265620 WP_004192395.1 NZ_CP113216:c4862584-4862300 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT265620 WP_004192397.1 NZ_CP113216:c4862816-4862574 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References