Detailed information of TA system TA026562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2340590..2341119
• Replicon: chromosome
• Accession: NC_017331
• Organism: Staphylococcus aureus subsp. aureus TW20

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SATW20_RS12055
• Protein ID: WP_000621175.1
• Coordinates: 2340590..2340952 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: SATW20_RS12060
• Protein ID: WP_000948331.1
• Coordinates: 2340949..2341119 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SATW20_RS12030	2337569..2338339	-	771	WP_001041103.1	RNA polymerase sigma factor SigB	-
SATW20_RS12035	2338314..2338793	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
SATW20_RS12040	2338795..2339121	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SATW20_RS12045	2339240..2340241	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
SATW20_RS12055	2340590..2340952	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SATW20_RS12060	2340949..2341119	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SATW20_RS12065	2341204..2342352	-	1149	WP_001281145.1	alanine racemase	-
SATW20_RS12070	2342418..2342777	-	360	WP_000581200.1	holo-ACP synthase	-
SATW20_RS12075	2342781..2343272	-	492	WP_001205910.1	PH domain-containing protein	-
SATW20_RS12080	2343259..2344842	-	1584	WP_001294626.1	PH domain-containing protein	-
SATW20_RS12085	2344835..2345314	-	480	WP_001287088.1	hypothetical protein	-
SATW20_RS12090	2345522..2346082	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T26562 WP_000621175.1 NC_017331:c2340952-2340590 [Staphylococcus aureus subsp. aureus TW20]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T26562 NC_017331:c2340952-2340590 [Staphylococcus aureus subsp. aureus TW20]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT26562 WP_000948331.1 NC_017331:c2341119-2340949 [Staphylococcus aureus subsp. aureus TW20]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT26562 NC_017331:c2341119-2340949 [Staphylococcus aureus subsp. aureus TW20]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1