Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2702916..2704504 Replicon chromosome
Accession NZ_CP113216
Organism Klebsiella pneumoniae strain SCLC9-2

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag OT489_RS13485 Protein ID WP_004190166.1
Coordinates 2702916..2704238 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OT489_RS13490 Protein ID WP_002904790.1
Coordinates 2704238..2704504 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT489_RS13470 (2697972) 2697972..2700473 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
OT489_RS13475 (2700461) 2700461..2701465 + 1005 WP_004190163.1 fimbrial protein -
OT489_RS13480 (2701607) 2701607..2702899 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OT489_RS13485 (2702916) 2702916..2704238 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
OT489_RS13490 (2704238) 2704238..2704504 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OT489_RS13495 (2704769) 2704769..2705095 - 327 WP_004143476.1 hydroxyisourate hydrolase -
OT489_RS13500 (2705092) 2705092..2705592 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OT489_RS13505 (2705570) 2705570..2706949 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OT489_RS13510 (2707295) 2707295..2708449 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OT489_RS13515 (2708430) 2708430..2709353 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T265615 WP_004190166.1 NZ_CP113216:c2704238-2702916 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT265615 WP_002904790.1 NZ_CP113216:c2704504-2704238 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References